Effect of inhaled corticosteroids on bronchial hyperresponsiveness in patients with mild asthma

Asian Pac J Allergy Immunol. 1995 Dec;13(2):81-5.


We studied the effect of inhaled budesonide on bronchial hyperresponsiveness (BHR) in twenty mild asthmatic patients. The study was conducted as a randomized, double-blind, placebo-controlled study. Before entering the study, the patients performed methacholine inhalation challenge (MIC) using a reservoir method to assess BHR. Then, they were randomly allocated to receive budesonide turbuhaler (200 micrograms/dose) or placebo turbuhaler two inhalations, twice daily for eight weeks. During the study, each patient recorded daily asthma score and daily number of puffs of beta 2 agonist and they were assessed at weeks 4 and 8. At the end of the treatment, MIC was repeated again. Patients receiving budesonide showed a significant improvement in airway responsiveness compared with those receiving placebo (p < 0.05). They also showed a significant improvement in asthma severity score and a significant decrease in beta 2 agonist bronchodilator use. This study also suggested that inhaled corticosteroids may be the primary treatment in patients, even with mild asthmatic and well-controlled symptoms.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Asthma / drug therapy*
  • Bronchial Hyperreactivity / drug therapy*
  • Bronchoconstrictor Agents / pharmacology
  • Bronchodilator Agents / pharmacology
  • Bronchodilator Agents / therapeutic use*
  • Budesonide
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Methacholine Chloride / pharmacology
  • Pregnenediones / pharmacology
  • Pregnenediones / therapeutic use*
  • Pulmonary Ventilation / drug effects


  • Anti-Inflammatory Agents
  • Bronchoconstrictor Agents
  • Bronchodilator Agents
  • Pregnenediones
  • Methacholine Chloride
  • Budesonide