[The ecdysteroid fraction of the above-ground portion of Serratula coronata L. in the spontaneous E-rosette formation reaction and the agar migration test in vitro]

Eksp Klin Farmakol. 1996 Jan-Feb;59(1):55-7.
[Article in Russian]

Abstract

Reaction of E-rosette formation and agar migration test in vitro showed that small concentrations (7.5.10(-13) -7.5.10(-8) M) of phytosteroid ecdysterone (20-hydroxyecdysone) induce the activation of human lymphocytes. The effect of higher concentrations (7.5.10(-7) -7.5.10(-5) M) is less pronounced (two-phase effect).

Publication types

  • English Abstract

MeSH terms

  • Agar
  • Blood Donors
  • Cell Movement / drug effects
  • Cell Movement / immunology
  • Dose-Response Relationship, Drug
  • Ecdysteroids
  • Ecdysterone / pharmacology
  • Erythrocytes / drug effects*
  • Erythrocytes / immunology
  • Humans
  • Leukocytes / drug effects
  • Leukocytes / immunology
  • Lymphocyte Activation / drug effects
  • Lymphocytes / drug effects
  • Lymphocytes / immunology
  • Plant Extracts / pharmacology*
  • Rosette Formation
  • Steroids / pharmacology*

Substances

  • Ecdysteroids
  • Plant Extracts
  • Steroids
  • Ecdysterone
  • Agar