Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 51 (4), 639-57

Lornoxicam. A Review of Its Pharmacology and Therapeutic Potential in the Management of Painful and Inflammatory Conditions

Affiliations
Review

Lornoxicam. A Review of Its Pharmacology and Therapeutic Potential in the Management of Painful and Inflammatory Conditions

J A Balfour et al. Drugs.

Abstract

Lornoxicam (chlortenoxicam), a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties, is available in oral and parenteral formulations. It is distinguished from established oxicams by a relatively short elimination half-life (3 to 5 hours), which may be advantageous from a tolerability standpoint. Data from preliminary clinical trials suggest that lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam was also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. Lornoxicam has a tolerability profile characteristic of an NSAID, with gastrointestinal disturbances being the most common adverse events. Limited clinical experience to date suggests that, as with a number of other NSAIDs, lornoxicam may provide a better-tolerated alternative or adjuvant to opioid analgesics for the management of moderate to severe pain. It has also demonstrated potential as an alternative to other NSAIDs for the management of arthritis and other painful and inflammatory conditions. These preliminary findings require confirmation in further comparative and long term studies.

Similar articles

See all similar articles

Cited by 25 PubMed Central articles

See all "Cited by" articles

References

    1. Lancet. 1994 Mar 26;343 (8900):769-72 - PubMed
    1. Drugs Aging. 1994 Feb;4(2):101-12 - PubMed
    1. Postgrad Med J. 1990;66 Suppl 4:S35-40 - PubMed
    1. J Chromatogr. 1993 Jul 23;617(1):105-10 - PubMed
    1. Drugs. 1994;47 Suppl 5:28-45; discussion 46-7 - PubMed

MeSH terms

LinkOut - more resources

Feedback