Insights on immunological aging derived from the T lymphocyte cellular senescence model

Exp Gerontol. 1996 Jan-Apr;31(1-2):21-7. doi: 10.1016/0531-5565(95)00017-8.


A human T cell culture system has been developed to study cellular senescence in a manner analogous to that used for fibroblasts. Using this system, several markers of replicative senescence have been identified. Evidence is provided to show that new insights into the immune deficiency of aging as well as HIV infection have emerged from the in vitro model. The culture model is now being exploited to dissect the basic mechanisms underlying the senescence program in T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CD28 Antigens / analysis
  • Cells, Cultured
  • Cellular Senescence*
  • Humans
  • Models, Biological
  • T-Lymphocytes / physiology*


  • CD28 Antigens