Abstract
Human immunodeficiency virus type 1 (HIV-1) tagged with the Escherichia coli supF gene has been used to clone integrated HIV-1 proviruses. Sequence analysis of the 600 to 800 bp of human DNA adjacent to 29 clones revealed a propensity for HIV-1 to integrate near the Alu class of human repetitive elements.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacteriophage lambda / genetics
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Base Sequence
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Cloning, Molecular
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Consensus Sequence
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DNA / chemistry
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DNA / genetics*
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DNA, Viral / genetics
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Escherichia coli / genetics
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Gene Deletion
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Genes, Bacterial
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Genes, Suppressor
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Genes, nef
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HIV-1 / genetics*
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Humans
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Molecular Sequence Data
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Proviruses / genetics
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RNA, Transfer / biosynthesis
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Repetitive Sequences, Nucleic Acid*
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Virus Integration*
Substances
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DNA, Viral
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supF tRNA
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DNA
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RNA, Transfer