Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in the rhinencephalic areas: a light and electron microscope study in the rat

Neurosci Lett. 1996 Mar 22;207(1):61-4. doi: 10.1016/0304-3940(96)12489-7.


The present study indicated presynaptic localization of a metabotropic glutamate receptor, mGluR8, in projection neurons of the main olfactory bulb of rat. An antibody was produced by using a peptide corresponding to C-terminal 23 amino acids of mouse mGluR8. It was confirmed that the C-terminal 23 amino acids of rat mGluR8 were the same as those of mouse mGluR8 except for one, and that the antibody specifically recognized mGluR8 in the rat rhinencephalon. In layer Ia of the piriform cortex (a target area of projection fibers from the main olfactory bulb), mGluR8-like immunoreactivity (mGluR8-LI) was reduced after transection of the lateral olfactory tract, and mGluR8-LI was observed in axon terminals which were filled with round synaptic vesicles and made asymmetric synapses with dendritic spines.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Base Sequence
  • Immunoblotting
  • Male
  • Mice
  • Molecular Sequence Data
  • Olfactory Bulb / metabolism*
  • Olfactory Bulb / ultrastructure
  • Polymerase Chain Reaction
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Metabotropic Glutamate / metabolism*
  • Sequence Homology, Nucleic Acid


  • Receptors, Metabotropic Glutamate