One billion years of Myb

Oncogene. 1996 Jul 18;13(2):223-35.

Abstract

The v-myb oncogene of the avian myeloblastosis virus has led to the discovery of a large and growing family of myb-related genes in a wide variety of eukaryotes including animals, plants, fungi and slime molds. The Myb-related proteins contain a highly conserved sequence, often present in multiple tandem repeats which constitute a DNA-binding domain. These proteins generally function in the regulation of cell growth and differentiation, often by coregulating gene expression along with DNA-binding proteins of other classes. This review focuses on the evolution of the myb gene family and the role of these genes in development.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Evolution
  • Humans
  • Molecular Sequence Data
  • Oncogene Proteins / genetics
  • Oncogene Proteins / physiology*
  • Oncogenes*

Substances

  • Oncogene Proteins