Incidence of leukaemia in young people around the La Hague nuclear waste reprocessing plant: a sensitivity analysis

Stat Med. 1995 Nov;14(21-22):2459-72. doi: 10.1002/sim.4780142114.


The objectives are to investigate the incidence of childhood leukaemia in young people around the French nuclear waste reprocessing plant (La Hague, Normandy) for the period 1978-1992, and to check the sensitivity of the results to the choice of disease clustering tests and reference rates. The performance of three statistical procedures are compared: a conventional approach; a Poisson maximum test, and an extraction mapping technique. On the whole, the results are in general agreement and demonstrate the apparent existence of a distinct cluster of childhood leukaemia, contiguous and south-east of the La Hague nuclear facility.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Child
  • Child, Preschool
  • Cluster Analysis*
  • Data Interpretation, Statistical
  • France / epidemiology
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Leukemia / epidemiology*
  • Leukemia, Radiation-Induced / epidemiology
  • Likelihood Functions
  • Models, Statistical*
  • Poisson Distribution
  • Radioactive Waste / adverse effects*
  • Reference Values
  • Reproducibility of Results
  • Retrospective Studies
  • Sensitivity and Specificity


  • Radioactive Waste