Effects of in vivo cocaine administration on human platelet aggregation

Am J Cardiol. 1996 Jul 15;78(2):237-9. doi: 10.1016/s0002-9149(96)90406-3.


To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent at high doses of adenosine diphosphate.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Analysis of Variance
  • Cocaine / blood
  • Cocaine / pharmacology*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nephelometry and Turbidimetry
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Prospective Studies


  • Platelet Aggregation Inhibitors
  • Cocaine