Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment

Annu Rev Med. 1996;47:413-21. doi: 10.1146/annurev.med.47.1.413.


Peripheral blood leukocytes interact with the vascular endothelium in a wide range of physiologic and pathophysiologic situations. A current working concept is that activation of vascular endothelium is an important event during the inflammatory response, conferring spatial and temporal localization and leukocyte-type selectivity to the recruitment process. This chapter highlights recent advances in our understanding of the endothelial-dependent molecular mechanisms that mediate recruitment of mononuclear leukocytes (lymphocytes and monocytes) and discusses these advances in the context of chronic inflammatory diseases and their potential therapeutic interventions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / physiology
  • Chronic Disease
  • Endothelium, Vascular / physiopathology*
  • Humans
  • Inflammation / immunology*
  • Leukocytes, Mononuclear / immunology
  • Leukocytosis / immunology*
  • Lymphocytes / immunology


  • Cell Adhesion Molecules