zhx-1: a novel mouse homeodomain protein containing two zinc-fingers and five homeodomains

Biochem Biophys Res Commun. 1996 Jul 25;224(3):870-6. doi: 10.1006/bbrc.1996.1114.


A cDNA encoding the complete reading frame of a novel homeodomain-containing protein, named zhx-1, has been cloned from a mouse bone marrow stromal cell line. The ORF encodes a protein of 873 amino acids, in which two C2-H2 zinc-fingers and five homeodomains have been identified. These features classify zhx-1 as a member of the ZF class of homeodomain transcription factors, zhx-1 mRNA is widely expressed in adult mouse, although it is preferentially expressed in brain. At least, two homologous mRNAs are present in humans suggesting that zhx-1 is the first member of a novel subclass of homeodomain factors.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • DNA, Complementary
  • Homeodomain Proteins / genetics*
  • Mice
  • Molecular Sequence Data
  • Open Reading Frames
  • RNA, Messenger / genetics
  • Sequence Homology, Amino Acid
  • Transcription Factors / genetics*
  • Zinc Fingers*


  • DNA, Complementary
  • Homeodomain Proteins
  • RNA, Messenger
  • Transcription Factors
  • Zhx1 protein, mouse

Associated data

  • GENBANK/Z52400
  • GENBANK/Z54200