Abstract
Epstein-Barr virus achieves its ubiquitous and uniform epidemiological distribution by a dual strategy of latency to guarantee lifelong persistence and intermittent replication to guarantee transmission. These two functions appear to dictate residence in different cell types: latency in B lymphocytes and replication in epithelial cells. Both of these cell compartments are potential sites for EBV-associated malignancies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Burkitt Lymphoma / virology
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Gene Expression Regulation, Viral*
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Genes, Viral
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Genome, Viral
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / growth & development
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Herpesvirus 4, Human / pathogenicity
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Herpesvirus 4, Human / physiology*
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Hodgkin Disease / virology
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Infectious Mononucleosis / virology
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Nasopharyngeal Neoplasms / virology
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Virus Latency
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Virus Replication