Immunopharmacology of rapamycin

Annu Rev Immunol. 1996;14:483-510. doi: 10.1146/annurev.immunol.14.1.483.

Abstract

The potent immunosuppressive drugs FK506 and rapamycin interfere with signal transduction pathways required for T cell activation and growth. The distinct inhibitory effects of these drugs on the T cell activation program are mediated through the formation of pharmacologically active complexes with members of a family of intracellular receptors termed the FK506 binding proteins (FKBPs). The FKBP12.FK506 complex specifically binds to and inhibits calcineurin, a signaling protein required for transcriptional activation of the interleukin (IL)-2 gene in response to T cell antigen receptor engagement. The FKBP12. rapamycin complex interacts with a recently defined target protein termed the mammalian target of rapamycin (mTOR). Accumulating data suggest that mTOR functions in a previously unrecognized signal transduction pathway required for the progression of IL-2-stimulated T cells from G1 into the S phase of the cell cycle. Here we review the immunopharmacology of rapamycin, with particular emphasis on the characterization of mTOR.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunosuppressive Agents / immunology*
  • Immunosuppressive Agents / pharmacology*
  • Polyenes / immunology*
  • Polyenes / pharmacology*
  • Sirolimus

Substances

  • Immunosuppressive Agents
  • Polyenes
  • Sirolimus