Serotonin1A Receptors Are Increased in Postmortem Prefrontal Cortex in Schizophrenia

Brain Res. 1996 Feb 5;708(1-2):209-14. doi: 10.1016/0006-8993(95)01361-x.

Abstract

Serotonin-5-HT1A receptors were measured with [3H]8-hydroxy-2-(di-n-propyl)aminotetralin ([3H]8-OH-DPAT) in postmortem prefrontal cortex of 12 pairs of subjects with schizophrenia and age-matched control subjects. The saturation binding isotherms of [3H]8-OH-DPAT revealed high- and low-affinity binding sites. The density (Bmax) of the high-affinity sites was significantly elevated by an average of 79% in subjects with schizophrenia. The dissociation constant (Kd) of the high-affinity sites in subjects with schizophrenia was not significantly different from the control subjects. These results provide further evidence for a role of the serotonergic system in the pathophysiology of schizophrenia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / metabolism*
  • Adult
  • Autopsy
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Prefrontal Cortex / metabolism*
  • Prefrontal Cortex / pathology
  • Radioligand Assay
  • Receptors, Serotonin / analysis
  • Receptors, Serotonin / metabolism*
  • Receptors, Serotonin, 5-HT1
  • Reference Values
  • Schizophrenia / metabolism*
  • Schizophrenia / pathology
  • Tritium

Substances

  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Tritium
  • 8-Hydroxy-2-(di-n-propylamino)tetralin