No doubt, pediculosis capitis or Pediculus h. capitis infestation is an increasing health problem particularly among Egyptian children. Many chemical pediculocides are used with a variety of effectiveness and side effects. Meanwhile, Co-trimoxazole (Trimethoprim and sulphamethoxazole) have shown some pediculocidal action. In this paper, Co-trimoxazole was given to patients infested with pediculosis capitis. Prolonged course was needed to free the patients from adult and nymphal stages but not the eggs (nits). The results were discussed. It was concluded that until the discovery of cheap, safe and effective oral drug, topical application of pediculocides as ointment or shampoo is the method of choice.