Clozapine treatment of euphoric mania

Ann Clin Psychiatry. 1995 Dec;7(4):203-6. doi: 10.3109/10401239509149626.


Four patients with treatment-resistant euphoric mania characterized by elevated mood, hyperactivity, and rapid speech, refractory to standard treatments and anticonvulsants, showed dramatic improvement in symptoms when treated with clozapine. All developed enhanced functioning and new insight into previous psychopathology. This degree of improvement suggests that clozapine can be considered in the treatment of not only schizophrenia, schizoaffective disorder, and dysphoric mania but also classic euphoric mania unresponsive to traditional treatments.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use*
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / psychology
  • Clozapine / administration & dosage
  • Clozapine / therapeutic use*
  • Euphoria / drug effects*
  • Female
  • Humans
  • Male
  • Psychiatric Status Rating Scales


  • Antipsychotic Agents
  • Clozapine