Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT

Lymphology. 1996 Mar;29(1):29-35.


Fifty seven patients with secondary lymphedema of the upper limb after previous treatment for breast cancer were treated for 3 months with an extract of Ruscus + Hesperidin Methyl Chalcone (CYCLO 3 FORT) or placebo according to a double-blind protocol in the context of a controlled clinical trial. All patients also underwent manual lymphatic drainage twice a week for at least one month. With CYCLO 3 FORT, the reduction in volume of arm edema, the main assessment criteria, was 12.9% after 3 months of treatment as compared with a placebo (p=0.009). Decreased edema tended to be more marked in the forearm compared with the upper arm where excess fat deposition seemed to dominate over excess fluid accumulation. CYCLO 3 FORT was well tolerated with minimal adverse reaction.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Arm / pathology
  • Breast Neoplasms / therapy
  • Double-Blind Method
  • Drainage / methods
  • Drug Administration Schedule
  • Female
  • Humans
  • Lymphedema / diagnosis
  • Lymphedema / drug therapy*
  • Lymphedema / etiology
  • Plant Extracts / therapeutic use*
  • Time Factors
  • Vasodilator Agents / therapeutic use*


  • Plant Extracts
  • Vasodilator Agents
  • cyclo 3