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Review
, 6 (2), 176-84

Special HATs for Special Occasions: Linking Histone Acetylation to Chromatin Assembly and Gene Activation

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Review

Special HATs for Special Occasions: Linking Histone Acetylation to Chromatin Assembly and Gene Activation

J E Brownell et al. Curr Opin Genet Dev.

Abstract

Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates chromatin structure to create new patterns of transcription.

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