Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

Curr Opin Genet Dev. 1996 Apr;6(2):176-84. doi: 10.1016/s0959-437x(96)80048-7.

Abstract

Post-translational acetylation of the core histone amino-terminal tails has long been associated with both chromatin assembly and the regulation of gene expression. The recent identification and cloning of histone acetyltransferase genes represents a significant breakthrough in our understanding of how specific acetylation states are established. Ongoing characterization of these enzymes and their molecular cohorts supports a direct role for acetylation in a signaling pathway that modulates chromatin structure to create new patterns of transcription.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases / physiology*
  • Amino Acid Sequence
  • Chromatin / metabolism*
  • Gene Expression Regulation / physiology*
  • Histone Acetyltransferases
  • Histones / metabolism
  • Molecular Sequence Data
  • Saccharomyces cerevisiae Proteins*
  • Transcriptional Activation

Substances

  • Chromatin
  • Histones
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases