Boundary and insulator elements in chromosomes

Curr Opin Genet Dev. 1996 Apr;6(2):185-92. doi: 10.1016/s0959-437x(96)80049-9.

Abstract

Recent progress in understanding boundary and insulator elements has concentrated on the identification of their protein components. BEAF-32 is a protein present in the scs' element of Drosophila that is also localized to most interband regions and puffs of polytene chromosomes, suggesting a role in the organization of structural chromosomal domains. The suppressor of Hairy-wing and modifier of mdg4 proteins have been characterized as components of the gypsy insulator. The latter seems to play a crucial role in conferring on the insulator its ability to unidirectionally affect enhancer function.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Nuclear
  • Chromosomes / chemistry*
  • DNA-Binding Proteins / physiology*
  • Drosophila
  • Enhancer Elements, Genetic / physiology
  • Gene Expression Regulation / physiology*
  • Humans
  • Nuclear Proteins / physiology*

Substances

  • Antigens, Nuclear
  • DNA-Binding Proteins
  • Nuclear Proteins