Pharmacokinetics and brain distribution of magnolol in the rat after intravenous bolus injection

J Pharm Pharmacol. 1996 Jan;48(1):57-9. doi: 10.1111/j.2042-7158.1996.tb05877.x.


The pharmacokinetics of magnolol in rats was studied after 2, 5, or 10 mg/kg-1 intravenous bolus injection. Plasma concentration-time profiles of magnolol were fitted by a two-compartment open model. There were no significant differences in the elimination half-life, the total body clearance, steady-state volume of distribution, or mean residence time. The area under the plasma-time curve and area under the moment-time curve of magnolol appears to increase proportionally from a dose of 2 to 10 mg/kg-1. These results suggest that magnolol possess linear pharmacokinetics. Notwithstanding, brain concentration of magnolol showed no significant difference among various regions (cerebral cortex, olfactory bulb, hippocampus, striatum, cerebellum, brain stem and rest of brain) after 10 min of magnolol (5 mg/kg-1, i.v.) administration, the mean brain drug concentration was approximately fourfold that of magnolol in plasma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biphenyl Compounds / administration & dosage
  • Biphenyl Compounds / blood
  • Biphenyl Compounds / pharmacokinetics*
  • Brain / metabolism*
  • Central Nervous System Depressants / administration & dosage
  • Central Nervous System Depressants / blood
  • Central Nervous System Depressants / pharmacokinetics*
  • Chromatography, High Pressure Liquid
  • Injections, Intravenous
  • Lignans*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Reproducibility of Results
  • Software
  • Statistics as Topic
  • Tissue Distribution


  • Biphenyl Compounds
  • Central Nervous System Depressants
  • Lignans
  • magnolol