Abstract
The recently determined structures of the ligand-binding domains from three nuclear receptors show that a receptor undergoes a significant conformational change on ligand binding. It is not yet clear how this structural change results in transcriptional activation.
MeSH terms
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism
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Humans
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Ligands
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Protein Conformation
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Receptors, Cytoplasmic and Nuclear / chemistry*
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Receptors, Retinoic Acid / chemistry
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Receptors, Retinoic Acid / metabolism
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Retinoic Acid Receptor gamma
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Retinoid X Receptors
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Transcription Factors / chemistry
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Transcription Factors / metabolism
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Transcriptional Activation*
Substances
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DNA-Binding Proteins
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Receptors, Retinoic Acid
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Retinoid X Receptors
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Transcription Factors