Transcriptional control: how nuclear receptors get turned on

Curr Biol. 1996 Apr 1;6(4):372-4. doi: 10.1016/s0960-9822(02)00498-0.

Abstract

The recently determined structures of the ligand-binding domains from three nuclear receptors show that a receptor undergoes a significant conformational change on ligand binding. It is not yet clear how this structural change results in transcriptional activation.

Publication types

  • Review

MeSH terms

  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Humans
  • Ligands
  • Protein Conformation
  • Receptors, Cytoplasmic and Nuclear / chemistry*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Retinoic Acid / chemistry
  • Receptors, Retinoic Acid / metabolism
  • Retinoic Acid Receptor gamma
  • Retinoid X Receptors
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism
  • Transcriptional Activation*

Substances

  • DNA-Binding Proteins
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Retinoic Acid
  • Retinoid X Receptors
  • Transcription Factors