Acute renal failure induced by angiotensin converting enzyme inhibitor in a patient with polyarteritis nodosa

Ren Fail. 1996 Mar;18(2):293-8. doi: 10.3109/08860229609052799.


We report a patient who presented with malignant hypertension and renal failure. He was treated with lisinopril, spironolactone, and nifedipine retard for blood pressure control. Subsequent renal function showed further deterioration, but it then improved after withdrawal of the angiotensin converting enzyme inhibitor (ACE I). The diagnosis of classical polyarteritis nodosa was established with aneurysmal dilatation demonstrable in the renal vasculature. His renal impairment improved further following immunosuppressive therapy and the disease has remained inactive 4 years after first presentation. This is the first reported case of acute renal failure associated with the use of ACE I in polyarteritis nodosa.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / diagnosis
  • Adult
  • Angiotensin-Converting Enzyme Inhibitors / adverse effects*
  • Antihypertensive Agents / therapeutic use
  • Chronic Disease
  • Drug Therapy, Combination
  • Humans
  • Hypertension, Malignant / complications
  • Hypertension, Malignant / diagnosis
  • Hypertension, Malignant / drug therapy
  • Hypertension, Malignant / etiology
  • Lisinopril / adverse effects*
  • Male
  • Polyarteritis Nodosa / complications*
  • Polyarteritis Nodosa / diagnosis


  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Lisinopril