Long-term clinical outcome of post-cholecystectomy patients with biliary-type pain: results of manometry, non-invasive techniques and endoscopic sphincterotomy

Eur J Gastroenterol Hepatol. 1996 Mar;8(3):245-9. doi: 10.1097/00042737-199603000-00011.


Objective: The purpose of the present study was to investigate prospectively the value of manometry, non-invasive techniques and endoscopic sphincterotomy in biliary type II and III patients with suspected sphincter of Oddi dysfunction.

Methods: All patients (n = 31) had undergone a cholecystectomy from 1 to 45 years before entry into the study, and had a history of biliary-type pain ranging from 4 to 156 months. In a primary diagnostic work-up, including ERCP, other causes of gastrointestinal disease were excluded. The width of the common bile duct, pain induced by the injection of contrast medium into the common bile duct, delayed contrast drainage and the results of a morphine-neostigmine test were analysed. Manometric measurements of basal sphincter of Oddi pressure were performed. Twenty-three patients with an elevated basal pressure (> 40 mmHg) underwent endoscopic sphincterotomy.

Results: During the follow-up period (8-62 months) 83% of the patients became symptom free or experienced an improvement. Basal sphincter of Oddi pressure and long-term clinical outcome of patients correlated to different degrees with the results of non-invasive techniques.

Conclusions: Our data suggest that endoscopic sphincterotomy may be an effective therapeutic modality in group II and III patients with sphincter of Oddi dysfunction in whom other gastrointestinal disorders have previously been excluded.

MeSH terms

  • Adult
  • Aged
  • Cholangiopancreatography, Endoscopic Retrograde
  • Cholecystectomy*
  • Cholinesterase Inhibitors
  • Common Bile Duct / diagnostic imaging
  • Common Bile Duct / pathology
  • Common Bile Duct / physiopathology
  • Common Bile Duct Diseases / diagnosis*
  • Common Bile Duct Diseases / diagnostic imaging
  • Common Bile Duct Diseases / therapy
  • Contrast Media
  • Female
  • Follow-Up Studies
  • Humans
  • Injections
  • Longitudinal Studies
  • Male
  • Manometry*
  • Middle Aged
  • Morphine
  • Narcotics
  • Neostigmine
  • Pain
  • Pressure
  • Prospective Studies
  • Sphincter of Oddi / diagnostic imaging
  • Sphincter of Oddi / pathology
  • Sphincter of Oddi / physiopathology
  • Sphincterotomy, Endoscopic*
  • Treatment Outcome


  • Cholinesterase Inhibitors
  • Contrast Media
  • Narcotics
  • Neostigmine
  • Morphine