Localized 2D J-resolved 1H MR spectroscopy of human brain tumors in vivo

J Magn Reson Imaging. May-Jun 1996;6(3):453-9. doi: 10.1002/jmri.1880060307.


Application of two-dimensional (2D) J-resolved MR spectroscopy, fully localized in three dimensions to monitor the metabolites in human brain tumors in vivo on a whole body MR scanner is presented. A modified PRESS sequence with [90 degrees - 180 degrees - t1/2 - 180 degrees - t1/ 2-acquisition] was used for voxel localization (2D J point-resolved spectroscopy [PRESS]); chemical shift selective (CHESS) sequence was used for suppression of water. The incremental delay (t1/2) added to the intervals before and after the last slice-selective 180 degrees RF pulse allowed the monitoring of the J-evolution in a localized 2D NMR spectrum. The addition of the second frequency dimension in 2D J-resolved spectroscopy to encode the indirect spin-spin coupling allowed the visualization of lactate peaks not observed in the 1D MR spectrum because of severe overlap with lipid peaks. 2D spectra of a two-layer phantom with 100 mM alanine and corn oil and also from three patients with tumors are presented here. The 2D spectra show that the J-coupled lactate peaks could be separated even when the lipids peaks severely overlap.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / physiopathology
  • Brain Neoplasms / secondary
  • Energy Metabolism / physiology*
  • Female
  • Glioblastoma / diagnosis
  • Glioblastoma / physiopathology
  • Glioma / diagnosis
  • Glioma / physiopathology
  • Humans
  • Image Processing, Computer-Assisted / instrumentation*
  • Lipid Metabolism
  • Magnetic Resonance Imaging / instrumentation*
  • Magnetic Resonance Spectroscopy / instrumentation*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / physiopathology
  • Phantoms, Imaging