Differentiation of subsets of CD4+ and CD8+ T cells

Ciba Found Symp. 1995;195:42-50; discussion 50-4. doi: 10.1002/9780470514849.ch4.


Our knowledge of the cytokine secretion patterns of T cells and other cells is clearly becoming more complex. The T helper 1 (Th1) and Th2 patterns may represent the extremes of a spectrum of cytokine regulatory patterns controlled by several cell types. CD8+ T cells can also secrete either Th1-like or Th2-like cytokine patterns, and they can contribute to bystander B cell activation. Interactions occur between immune cytokine regulatory networks and other systems, and pregnancy and responses against infection can profoundly influence each other.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / cytology*
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / cytology*
  • CD8-Positive T-Lymphocytes / immunology
  • Cell Differentiation
  • Cytokines / metabolism
  • Female
  • Humans
  • Pregnancy
  • T-Lymphocyte Subsets / cytology*
  • T-Lymphocyte Subsets / immunology


  • Cytokines