Enhancement of hydralazine bioavailability by food

Clin Pharmacol Ther. 1977 Jul;22(1):104-7. doi: 10.1002/cpt1977221104.


The influence of food on the bioavailability of hydralazine in noncoated and coated tablets was examined in 5 healthy males. Each subject received an oral 50-mg dose on four different occasions: two 25-mg noncoated tablets with and without food and one 50-mg coated tablet with and without food. The meal was a standardized breakfast of 440 calories. Venous blood samples were obtained during a 6-hr period, and the plasma concentrations of unmetabolized hydralazine were assessed by a selective and sensitive gas chromatographic method. The results indicate that food enhances the bioavailability of hydralazine 2- to 3-fold both when noncoated and coated tablets are used.

MeSH terms

  • Adult
  • Biological Availability
  • Food*
  • Humans
  • Hydralazine / administration & dosage
  • Hydralazine / blood*
  • Kinetics
  • Male
  • Tablets
  • Time Factors


  • Tablets
  • Hydralazine