Tracking antigen-specific helper T cell responses

Curr Opin Immunol. 1996 Apr;8(2):278-84. doi: 10.1016/s0952-7915(96)80068-9.


T-cell receptor transgenic animals provide an excellent source of T cells for the analysis of antigen-specific helper T-cell development. Alternatively, studies in normal animals continue to focus on specific immune responses dominated by T cells using restricted sets of antigen receptors. These complementary strategies provide direct access to the dynamics of helper T-cell differentiation in vivo.

Publication types

  • Review

MeSH terms

  • Animals
  • Epitopes / analysis*
  • Epitopes / immunology*
  • Humans
  • T-Lymphocytes, Helper-Inducer / immunology*


  • Epitopes