CREB and the Formation of Long-Term Memory

Curr Opin Neurobiol. 1996 Apr;6(2):264-8. doi: 10.1016/s0959-4388(96)80082-1.


Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of the transcription factor accelerate the process. These results have led to the recent hypothesis that CREB is pivotal in the switch from short-term (protein synthesis independent) to long-term (protein synthesis dependent) memory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Aplysia / physiology
  • Cyclic AMP / physiology
  • Cyclic AMP Response Element-Binding Protein / genetics
  • Cyclic AMP Response Element-Binding Protein / physiology*
  • Drosophila / physiology
  • Genes, Switch
  • Memory / physiology*
  • Mice
  • Mice, Knockout / genetics


  • Cyclic AMP Response Element-Binding Protein
  • Cyclic AMP