Faecal calprotectin shedding after short-term treatment with non-steroidal anti-inflammatory drugs

Scand J Gastroenterol. 1996 Apr;31(4):339-44. doi: 10.3109/00365529609006407.


Background: Increased faecal calprotectin shedding indicates gastrointestinal mucosal inflammation.

Methods: We studied the effect of short-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) on faecal calprotectin shedding in two randomized crossover studies, with treatment regimens of indomethacin or naproxen for 14 days in the first study (n = 16) and lornoxicam or naproxen for 7 days in the second study (n = 18).

Results: The method's reproducibility and stability were satisfactory. Indomethacin and naproxen increased the faecal calprotectin significantly from a base line of 4.7 mg/l to 9.0 mg/l and 8.0 mg/l, respectively. Lornoxicam failed to increase the faecal calprotectin. Shedding after 7 days of naproxen treatment was positively correlated to gastroduodenal mucosal inflammation assessed by endoscopy.

Conclusions: Although seemingly influenced by concurrent upper airway infections, the study indicates that the calprotectin test may be useful for monitoring the inflammatory response to NSAID treatment, even in short-term setting.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Cross-Over Studies
  • Feces / chemistry*
  • Gastric Mucosa / pathology
  • Humans
  • Indomethacin / adverse effects
  • Inflammation / chemically induced
  • Intestinal Mucosa / pathology
  • Leukocyte L1 Antigen Complex
  • Male
  • Naproxen / adverse effects
  • Neural Cell Adhesion Molecules / analysis*
  • Piroxicam / adverse effects
  • Piroxicam / analogs & derivatives
  • Reproducibility of Results


  • Anti-Inflammatory Agents, Non-Steroidal
  • Leukocyte L1 Antigen Complex
  • Neural Cell Adhesion Molecules
  • Piroxicam
  • Naproxen
  • lornoxicam
  • Indomethacin