Potential role of interleukin-1 in the development of bronchopulmonary dysplasia

J Interferon Cytokine Res. 1996 May;16(5):365-73. doi: 10.1089/jir.1996.16.365.


Increased activities of inflammatory mediators unopposed by their inhibitors contribute to chronic lung injury and impaired healing in BPD. The deleterious effects of IL-1 beta, a cytokine involved in inflammation and host defense, are blocked by IL-1 receptor antagonist (IL-1Ra). We proposed that an imbalance of IL-1 beta and its inhibitors may contribute to the development of BPD. To determine the relative antigen concentrations of IL-1 beta and IL-1Ra and functional IL-1 activity in lung lavage of infants at risk for BPD, lung lavage was serially obtained from 1 to 28 days from 17 infants with evolving BPD, 13 infants with self-limited RDS, and 6 controls ventilated for nonpulmonary reasons. Overall, there was a high correlation between IL-1 beta antigen concentration and IL-1 activity (r = 0.82, p = 0.0001). There were no significant differences among the groups for lung lavage variables on day 1. However, in infants who developed BPD, IL-1 beta antigen concentration and IL-1 activity increased 16- and 61-fold, respectively, during the first week. IL-1Ra remained relatively unchanged during the first month. IL-1 beta/IL-1Ra antigen ratio was significantly higher on days 5 (median 0.024) and 7 (median 0.025) compared with day 1 (median 0.004), p < 0.05. These results suggest that a relative imbalance of IL-1 beta and IL-1Ra may contribute to prolonged inflammation in BPD.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bronchoalveolar Lavage Fluid
  • Bronchopulmonary Dysplasia / drug therapy*
  • Bronchopulmonary Dysplasia / immunology
  • Bronchopulmonary Dysplasia / physiopathology
  • Case-Control Studies
  • Female
  • Humans
  • Infant, Newborn
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / antagonists & inhibitors*
  • Interleukin-1 / immunology
  • Interleukin-1 / physiology*
  • Male
  • Recombinant Proteins / pharmacology
  • Sialoglycoproteins / immunology
  • Sialoglycoproteins / pharmacology*


  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Recombinant Proteins
  • Sialoglycoproteins