Pain relief with low-dose intravenous clonidine in a child with severe burns

Intensive Care Med. 1996 Mar;22(3):249-51. doi: 10.1007/BF01712245.


The case of an 11-year-old boy who suffered second and third degree burns to 78% of his body is reported. The large doses of morphine used as analgesia resulted in severe side effects: ventilatory dependence, impairment of gastrointestinal function and psychological disturbance. Intravenous lignocaine was added without benefit. The addition of low-dose intravenous clonidine, however, precipitated a dramatic reduction in morphine consumption with an attendant improvement in ventilatory, gastrointestinal and psychological functions.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic alpha-Agonists / therapeutic use*
  • Analgesics, Opioid / adverse effects
  • Burns / complications*
  • Child
  • Clonidine / therapeutic use*
  • Drug Therapy, Combination
  • Humans
  • Infusions, Intravenous
  • Male
  • Morphine / adverse effects
  • Pain / drug therapy*
  • Pain / etiology


  • Adrenergic alpha-Agonists
  • Analgesics, Opioid
  • Morphine
  • Clonidine