Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

Trends Microbiol. 1996 May;4(5):175-9. doi: 10.1016/0966-842x(96)10026-3.


Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aged
  • Animals
  • Base Sequence
  • Cardiomyopathy, Dilated / virology*
  • Coxsackievirus Infections / virology*
  • Enterovirus B, Human / genetics*
  • Enterovirus B, Human / pathogenicity*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Myocarditis / virology*
  • Virulence