Understanding Signal Transduction During Bacterial Infection

Trends Microbiol. 1996 Apr;4(4):141-6. doi: 10.1016/0966-842x(96)10024-x.


Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Bordetella Infections / microbiology*
  • Gene Expression Regulation, Bacterial
  • Humans
  • Signal Transduction*
  • Transcription Factors / genetics
  • Transcription Factors / physiology


  • Bacterial Proteins
  • BvgA protein, Bacteria
  • Transcription Factors
  • bvgS protein, Bordetella pertussis