Initial treatment of microbial keratitis

CLAO J. 1996 Apr;22(2):136-40.


Purpose: The common occurrence of failed medical treatment in microbial keratitis led us to investigate this phenomenon.

Methods: We retrospectively reviewed all ulcers that presented to our department for 24 consecutive months. We classified each ulcer as either a therapeutic success or failure based on a precise definition of the response to initial antibiotic selection. We then analyzed multiple factors including: antibiotic selection, ophthalmic disease, ulcer characteristics, and management, to determine their significance in the success or failure in treating microbial keratitis. Complications were also examined.

Results: Important factors in failure were non-fortified antibiotics (P < 0.001), ocular surface disease (P = 0.0178) and outpatient management (P < 0.001). Large ulcers (P = 0.051) were of borderline significance. Sensitivity results reflect high sensitivity among successfully treated patients when appropriate antibiotics are chosen.

Conclusions: This report provides insight into current practice patterns and potential means to improve success in managing microbial keratitis.

MeSH terms

  • Ambulatory Care
  • Anti-Bacterial Agents / therapeutic use
  • Contact Lenses / adverse effects
  • Corneal Ulcer / etiology
  • Corneal Ulcer / therapy
  • Humans
  • Infections*
  • Keratitis / complications
  • Keratitis / drug therapy*
  • Keratitis / microbiology*
  • Retrospective Studies
  • Treatment Outcome


  • Anti-Bacterial Agents