Mechanisms of phagocytosis

Curr Opin Immunol. 1996 Feb;8(1):36-40. doi: 10.1016/s0952-7915(96)80102-6.


Recent advances in research on phagocytosis include a better appreciation of the cross-talk between phagocytic receptors, the definition of multiple signaling domains within these receptors, and a deeper understanding of the downstream effector pathways leading to actin polymerization and particle internalization. Phagosome maturation in macrophages proceeds via a series of membrane fusion and fission events, which modify the phagosome in small increments, and appears to be regulated, in part, by GTP-binding proteins and perhaps by protein kinase C. The isolation of dysphagic mutants of Dictyostelium discoideum presages the identification of new genes required for phagocytosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism
  • Actins / physiology
  • Leukocytes, Mononuclear / immunology
  • Neutrophils / immunology
  • Phagocytosis* / genetics
  • Phagocytosis* / immunology
  • Phagosomes / metabolism
  • Phagosomes / microbiology
  • Receptors, Cell Surface / physiology
  • Signal Transduction


  • Actins
  • Receptors, Cell Surface