Human minor histocompatibility antigens

Curr Opin Immunol. 1996 Feb;8(1):75-81. doi: 10.1016/s0952-7915(96)80108-7.

Abstract

Disparities in minor histocompatibility antigens between HLA-matched organ and bone marrow donors and recipients create a potential risk for graft failure and graft-versus-host disease. These conditions necessitate lifelong pharmacological immunosuppression of organ and bone marrow transplant recipients. Recent technical advances have resulted in the identification of the chemical nature of the first human minor histocompatibility antigens. A new era of research has begun to provide insights into the genetics of minor antigens and their putative role in transplantation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Marrow Transplantation / adverse effects
  • Gene Expression Regulation
  • Graft vs Host Disease / immunology
  • Humans
  • Minor Histocompatibility Antigens* / genetics
  • Minor Histocompatibility Antigens* / immunology
  • Minor Histocompatibility Antigens* / isolation & purification
  • Organ Transplantation / adverse effects
  • Polymorphism, Genetic
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Helper-Inducer / immunology

Substances

  • Minor Histocompatibility Antigens