Increased amounts of C3a and the terminal complement complex at high dialysis blood-flow: the relation with dialysis efficiency

Nephron. 1996;72(4):523-9. doi: 10.1159/000188933.

Abstract

To estimate the influence of blood-flow on complement generation and the relation with dialysis efficacy (KT/V) 10 patients underwent cuprophan hemodialyses for 6 h using low (200 ml/min) or high (400 ml/min) blood-flow (n = 40). Dialysis with high blood-flow compared to low induced a more rapid drop in leukocyte count and a more pronounced leukocyte rebound. Net generation of C3a (microgram/min) was also larger at all 15 measuring points during high blood-flow dialysis and there was significantly larger total generation of C3a (after 3 h p < 0.05, after 6 h p < 0.05) as compared to low blood-flow. Reaching a KT/V of 1.2-1.4 with high blood-flow induced a 40% larger total net generation of C3a and 21% more of TCC than with low blood-flow. Net generation of TCC (AU/min) was higher during the first and last parts of high blood-flow dialysis compared to low. In conclusion, increased blood-flow in order to increase dialysis efficiency (KT/V 1.2-1.4) results in larger net infusion of complement products with possible impact on immune response and complement-associated pathophysiological mechanisms.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complement C3a / metabolism*
  • Complement Membrane Attack Complex / metabolism*
  • Female
  • Humans
  • Leukocyte Count
  • Male
  • Middle Aged
  • Renal Circulation / physiology*
  • Renal Dialysis*

Substances

  • Complement Membrane Attack Complex
  • Complement C3a