Objective: The experience of our group in the characterization of the cryoglobulins during the last 8 years is reported, and the possible advantages of immunofixation versus immunoblotting are discussed.
Methods: 25 out of 171 cryoprecipitates studied by immunofixation were also examined by immunoblotting, a technique which has been suggested to offer advantages in analysing monoclonal components.
Results: We confirm that immunofixation may be the technique of choice given its easier execution and interpretation, better standardization, and lower overall cost.