The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer

Cell Signal. 1996 Feb;8(2):87-95. doi: 10.1016/0898-6568(95)02034-9.


Quantitative analysis of the proteins which compromise the stimulatory arm of the adenylyl cyclase cascade indicate that the adenylyl cyclase catalytic component is usually the least highly expressed. The effects on both potency of agonist ligands and maximal output resulting from targetted alterations in expression levels of each element of this cascade are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenylyl Cyclases / chemistry*
  • Adenylyl Cyclases / genetics*
  • Adenylyl Cyclases / metabolism
  • Animals
  • Gene Expression Regulation, Enzymologic / physiology
  • Humans
  • Signal Transduction / physiology*


  • Adenylyl Cyclases