Cellular organization of lateral hypothalamic efferents to the central amygdaloid nucleus of the rat

Neuroreport. 1996 Jan 31;7(2):517-20. doi: 10.1097/00001756-199601310-00034.


The present study aimed to describe the localization, organization and density of lateral hypothalamic neurones projecting to the central amygdaloid nucleus (CeA) using WGA-apoHRP-Au as a retrograde tracer. In the lateral hypothalamus (LH) a cluster of labelled neurones was located in the middle and posterior parts of this region. This retrograde labelling is organized into perifornical and juxtacapsular subpopulations. These results provide a neuroanatomical basis for the concept that these lateral hypothalamic neurones modulate projections from CeA to pons and brainstem autonomic and gustatory centres which integrate responses related to fundamental and adaptive behaviours, and could be related to self-stimulation behaviour elicited from the CeA.

MeSH terms

  • Amygdala / anatomy & histology
  • Amygdala / cytology*
  • Amygdala / physiology
  • Animals
  • Efferent Pathways / anatomy & histology
  • Efferent Pathways / cytology
  • Efferent Pathways / physiology
  • Gold Colloid
  • Histocytochemistry
  • Hypothalamic Area, Lateral / cytology*
  • Hypothalamic Area, Lateral / physiology
  • Male
  • Neurons, Efferent / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate


  • Gold Colloid
  • Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate