Neuroleptic malignant syndrome

Br J Hosp Med. 1996 Apr 17-30;55(8):517-20.


Neuroleptic malignant syndrome is a rare, idiosyncratic condition related to neuroleptic use which may develop at any stage during neuroleptic treatment and can prove fatal. Although most commonly seen in psychiatric patients, anyone prescribed a neuroleptic is at risk and it has been associated with other agents. This article discusses its recognition, risk factors, clinical course and treatment, together with a summary of current thinking on its aetiology.

Publication types

  • Review

MeSH terms

  • Antipsychotic Agents / adverse effects
  • Diagnosis, Differential
  • Dopamine Antagonists / adverse effects
  • Humans
  • Mental Disorders / drug therapy
  • Neuroleptic Malignant Syndrome / diagnosis*
  • Neuroleptic Malignant Syndrome / etiology
  • Neuroleptic Malignant Syndrome / physiopathology
  • Neuroleptic Malignant Syndrome / therapy
  • Receptors, Dopamine / drug effects
  • Risk Factors


  • Antipsychotic Agents
  • Dopamine Antagonists
  • Receptors, Dopamine