Comparison of the effects of astemizole/pseudoephedrine and triprolidine/pseudoephedrine on CNS activity and psychomotor function

Int Clin Psychopharmacol. 1996 Mar;11(1):31-6. doi: 10.1097/00004850-199603000-00004.


The sedative properties of astemizole-D and triprolidine-D were compared in a double-blind, placebo-controlled, repeated-measures design study comprising three experimental treatments, each with a duration of 2 days (n = 12). Sedation was assessed by continuous electroencephalographic measurement (C-EEG), intermittent performance testing and subjective measures. C-EEG monitoring revealed that triprolidine-D produced significantly more daytime sedation and drowsiness than either astemizole-D or placebo (p < 0.05). Intermittent performance testing did not reveal consistent psychomotor deficits. There were no differences from placebo; the only significant findings showed that astemizole-D improved tracking accuracy at T + 65 h (p < 0.05) compared to baseline. Also, when scores were summed across all time points, astemizole-D improved scores significantly in contrast to triprolidine-D for the total scores (p < 0.05). It is concluded that, in contrast to triprolidine-D, astemizole-D does not produce daytime drowsiness or sedation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Astemizole / adverse effects
  • Astemizole / pharmacology*
  • Delayed-Action Preparations
  • Double-Blind Method
  • Drug Therapy, Combination
  • Electroencephalography / drug effects
  • Ephedrine / pharmacology
  • Female
  • Histamine H1 Antagonists / adverse effects
  • Histamine H1 Antagonists / pharmacology*
  • Humans
  • Middle Aged
  • Sleep / drug effects
  • Sympathomimetics / pharmacology
  • Triprolidine / adverse effects
  • Triprolidine / pharmacology*


  • Delayed-Action Preparations
  • Histamine H1 Antagonists
  • Sympathomimetics
  • Triprolidine
  • Astemizole
  • Ephedrine