Sprouting of A beta fibers into lamina II of the rat dorsal horn in peripheral neuropathy

Neurosci Lett. 1996 Apr 26;208(3):147-50. doi: 10.1016/0304-3940(96)12566-0.


Cholera toxin beta-subunit conjugated to horseradish peroxidase was used to label the large myelinated (A beta) fiber input to the dorsal horn in a model of peripheral neuropathy induced by tight ligation of the L5 and L6 spinal nerves. Following induction of neuropathy, A beta fibers were present in lamina II of the ipsilateral dorsal horn, a region normally devoid of A beta input. This reorganization of large fiber input to the superficial dorsal horn provides some anatomical basis for sensory changes found in this model of neuropathic pain.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Afferent Pathways / physiology*
  • Animals
  • Disease Models, Animal
  • Histocytochemistry
  • Male
  • Microscopy, Electron
  • Nerve Fibers / ultrastructure*
  • Rats
  • Rats, Sprague-Dawley
  • Spinal Cord / ultrastructure*