The relationship between IgE-mediated and cell-mediated hypersensitivities in an unselected Danish population: the Glostrup Allergy Study, Denmark

Br J Dermatol. 1996 Apr;134(4):669-72. doi: 10.1111/j.1365-2133.1996.tb06967.x.

Abstract

In this study, we have assessed the relationship between IgE-mediated and cell-mediated hypersensitivities in an unselected population living in western Copenhagen, Denmark. A total of 793 subjects, aged 15-69 years, were studied. Measurements of total serum IgE, prick tests with aero-allergens and patch tests with environmental haptens were performed in 561 (70.7% of 793) subjects. One or more positive prick tests were present in 28.4%, and contact sensitization occurred in 15.2%. When adjusted for the effects of sex and age, the probability of contact sensitization to one or more hapten was independent of serum IgE level (the odds ratio value (OR) = 1.0; 95% confidence interval (CI) = 0.7-1.4), and the probability of contact sensitization was independent of the number of positive prick tests (OR = 1.0; CI = 0.8-1.2). Contact sensitization appeared to be independent of enhanced IgE responsiveness in an unselected adult population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Allergens / immunology
  • Dermatitis, Allergic Contact / immunology*
  • Female
  • Haptens / immunology
  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Immunity, Cellular
  • Immunoglobulin E / blood*
  • Intradermal Tests
  • Male
  • Middle Aged
  • Patch Tests

Substances

  • Allergens
  • Haptens
  • Immunoglobulin E