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, 134 (4), 710-4

Apoptosis as a Mechanism of Keratinocyte Death in Toxic Epidermal Necrolysis

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Apoptosis as a Mechanism of Keratinocyte Death in Toxic Epidermal Necrolysis

C Paul et al. Br J Dermatol.

Abstract

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening diseases characterized by extensive epidermal destruction. The aim of our study was to investigate apoptosis in keratinocytes of patients with TEN and TEN/SJS overlap syndrome. Keratinocytes from TEN patients were found to undergo extensive apoptosis. These results suggest that cell destruction in TEN occurs as a result of apoptosis. Our findings suggest that apoptosis inhibitory agents may play an important part in the therapeutic strategy of TEN.

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