Dynamic changes in expression of glutamate transporter mRNAs in developing brain

Neuroreport. 1996 Feb 29;7(3):705-9. doi: 10.1097/00001756-199602290-00006.


Developmental changes in gene expression for three glutamate transporter subtypes in the mouse brain were analysed by in situ hybridization. During embryonic stages, GluT-1 and GLT-1 mRNAs were expressed at high levels in the ventricular zone, whereas EAAC1 mRNA was not detected in the zone. In the mantle zone, transcription levels of three transporter mRNAs were low during embryonic stages, and these levels, especially those of the GluT-1 and GLT-1 mRNAs, displayed remarkable increases postnatally to reach maximal levels at 14 days of age. These dynamic developmental regulations suggest that the glutamate transporter not only regulates the excitatory synaptic transmission at mature stages, but might also be intimately involved in the brain development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / biosynthesis*
  • ATP-Binding Cassette Transporters / genetics
  • Amino Acid Transport System X-AG
  • Animals
  • Brain / embryology*
  • Brain Chemistry / genetics
  • Brain Chemistry / physiology*
  • Excitatory Amino Acids / pharmacology
  • Gene Expression Regulation, Developmental / physiology*
  • In Situ Hybridization
  • Mice
  • Mice, Inbred C57BL
  • Oligonucleotide Probes
  • RNA, Messenger / biosynthesis*
  • RNA, Messenger / genetics


  • ATP-Binding Cassette Transporters
  • Amino Acid Transport System X-AG
  • Excitatory Amino Acids
  • Oligonucleotide Probes
  • RNA, Messenger