Temporary improvement of neurological symptoms with gammaglobulin therapy in a boy with adrenoleukodystrophy

Brain Dev. Mar-Apr 1996;18(2):119-21. doi: 10.1016/0387-7604(95)00106-9.

Abstract

A 10-year-old boy with adrenoleukodystrophy was treated with gammaglobulin in conjunction with a mixture of glyceryl trioleate and glyceryl trierucate. With a high dose of gammaglobulin, clinical improvement, including the reduction of visual field defects, was noted. On magnetic resonance imaging, attenuation of the enhancement of the rim with gadolinium was observed, suggesting repair of the blood-brain barrier. When auditory agnosia developed later, a temporary improvement was again obtained with gammaglobulin. Although the progress of the disease could not be arrested permanently, gammaglobulin therapy seemed to have been associated with temporary improvement of the clinical symptoms in this patient with adrenoleukodystrophy.

Publication types

  • Case Reports

MeSH terms

  • Adrenoleukodystrophy / diet therapy
  • Adrenoleukodystrophy / therapy*
  • Brain / pathology
  • Child
  • Dietary Fats, Unsaturated / therapeutic use
  • Drug Combinations
  • Erucic Acids / therapeutic use
  • Humans
  • Injections, Intravenous
  • Magnetic Resonance Imaging
  • Male
  • Nervous System Diseases / chemically induced*
  • Nervous System Diseases / complications
  • Triolein / therapeutic use
  • Visual Fields / physiology
  • gamma-Globulins* / administration & dosage

Substances

  • Dietary Fats, Unsaturated
  • Drug Combinations
  • Erucic Acids
  • Lorenzo's oil
  • gamma-Globulins
  • Triolein