huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system

Mech Dev. 1996 Mar;55(1):53-64. doi: 10.1016/0925-4773(95)00490-4.


huckebein encodes a predicted zinc finger transcription factor which is transiently expressed in a subset of Drosophila central nervous system precursors (neuroblasts (NBs)). We used DiI cell lineage tracing and cell fate markers to investigate the role of huckebein in the NB 1-1 and NB 2-2 cell lineages. Loss of huckebein does not switch these NBs into different NB fates, nor does it change the number of cells in their lineages; rather, it is required for glial development in the NB 1-1 lineage, and for axon pathfinding of a subset of interneurons and motoneurons in both lineages.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / physiology*
  • Cell Line
  • Central Nervous System / cytology
  • Central Nervous System / embryology
  • DNA-Binding Proteins / physiology*
  • Drosophila / embryology
  • Drosophila Proteins*
  • Neuroglia / physiology*
  • Zinc Fingers*


  • DNA-Binding Proteins
  • Drosophila Proteins
  • Hkb protein, Drosophila