Abstract
The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials
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Analysis of Variance
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Animals
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Calcium / pharmacology*
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Charybdotoxin / pharmacology
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Crosses, Genetic
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Female
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Hippocampus / physiology*
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In Vitro Techniques
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Mice, Knockout
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Potassium Channels / drug effects
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Potassium Channels / physiology*
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Prions / genetics*
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology*
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Recombination, Genetic
Substances
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Potassium Channels
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Prions
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Charybdotoxin
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Calcium